The Role of Blood Microbiome and Microbial Product Translocation in Disease Pathogenesis_ Crimson Publishers

The Role of Blood Microbiome and Microbial Product Translocation in Disease Pathogenesis by Lei Huang* in Advancements in Case Studies_ Journal of Case Studies

 

Abstract
Circulation has been considered in a sterile condition in individuals without live microbial infections. However, recent publications from our group and others highlight detection of blood microbiome or microbial molecules in healthy individuals and individuals with various diseases, as well as their potential roles in disease pathogenesis. In this review, we introduce the published studies and research advancement in the field of blood microbial and microbial translocation in disease immunopathogenesis 

Introduction
Circulation has been considered in a sterile condition in individuals without live microbial infections. However, recent publications highlight detection of blood microbiome or microbial molecules in healthy individuals and individuals with various diseases without a live infection or sepsis. Due to the low blood levels of microbial biomass and background contaminations from experimental procedures, blood microbiome analysis has been met with technical challenges. Nonetheless, blood microbiome provides important information to study the interactions of microbiome and hosts, which is potentially critical for investigating their effects on host immune perturbations in various disease conditions. Blood and tissue microbiome have been studied in some fields. In a recent study, blood and tissue microbiome has been assessed and cancer-specific microbial sequences have been identified in different types of cancer in humans [1]. In another study with seven different type of cancer, evidence was found that cancer-specific bacteria were detected within both immune cells and cancer tissues

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Alzheimer’s Disease and Intestinal Microbiota Transplantation_ Crimson Publishers

 Alzheimer’s Disease and Intestinal Microbiota Transplantation by Saba Kanwal* in COJ Reviews & Research_ Research and Reviews International Journals

 

Abstract
Being an international organization, the United Nations has played an outstanding role in facilitating cooperation in international law, international security, economic development, social progress, human rights and maintenance of world peace. The pursuit of human rights has been remained a focus point in the objectives of the UN. The atrocities of the World War II and genocide, highlighted the need that the new organization must work to prevent any similar tragedies, which would be expected in the future, So on the basis of early objectives, the UN has created legal framework for considering and acting on complaints about human rights violations. The UN has succeeded to promote peace as well as to ensure human rights at global level. The UN ensuring human rights and peace through a special mechanism, peace-keeping missions and forces, state to state contact and through its observers. The apartheid in South Africa is one of the most painful examples of the human rights violation in which majority of black inhabitants were curtailed extremely based on racial segregation. The apartheid was developed after World War II by the Afrikaner-dominated National Party, and the UN stimulated this issue immediately at its first gathering in 1946, placing South Africa on the agenda. The UN successfully resolved the issue of human rights violations in South Africa, but ultimately it take very long time to eradicate apartheid from South Africa and after forty years, South Africa was able to conduct fare and free elections with cooperation of the UN and other international communities

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Seroprevalence of anti-Toxoplasma gondii Antibodies Among Aborted Ladies Attended to Atbara Teaching Hospital, River Nile State_ Crimson Publishers

 Seroprevalence of anti-Toxoplasma gondii Antibodies Among Aborted Ladies Attended to Atbara Teaching Hospital, River Nile State by Ali Elamin Nasir Hamad* in Advancements in Bioequivalence & Bioavailability_ Bioequivalence And Bioavailability International Journal

 

Abstract
This cross-sectional study was conducted in Atbara area-River Nile state throughout February to November 2017. The purpose of this study was to determine the sero-prevalence of Toxoplasmosis among aborted women. One hundred and fifty-two subjects with the age ranged between 25-49 years old of mean age was 38+10 were included. Blood samples were taken from all subjects. All samples were examined to detect Toxoplasma gondii antibodies by using Latex, ICT and ELISA techniques. The study showed that the overall sero-prevalence of Toxoplasma parasite by different techniques was as follows: 35.5% by ELISA technique, 33.6% by Latex agglutination technique and 22.4% by ICT technique.

The overall prevalence of antibodies increased gradually with age reaching 54.6% in the age group (41-49) year followed by 32.9% in age group (31-40) year, then 12.5% in age group (20-30) year. Assuming ELISA technique as the gold standard method, the sensitivity and specificity of the LATEX technique were 94% and 100%, and for ICT technique were 64% and 100% respectively. The study found that Toxoplasma antibodies are more prevalent in women in contact with cats than in women who do not contact with cats.

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The Effects of Detraining on Cardiovascular Parameters in Distance Runners_ Crimson Publishers

 The Effects of Detraining on Cardiovascular Parameters in Distance Runners by Gerasimos V Grivas* in Examines in Physical Medicine and Rehabilitation: Open Access_ Journal of Rehabilitation Medicine

 

Abstract
Detraining is the reduction of performance that happens after the cessation of training and is reflected by anatomic and physiologic changes. The purpose of this study was to investigate the effects of reduce training on cardiovascular parameters in distance runners. Many studies showed reduce of VO2 max and anaerobic threshold after detraining. On the other hand, only one study examined the effect of detraining on running economy and did not observe a decline

Introduction
Detraining is the partial or complete loss of training-induced adaptations, in response to an insufficient training stimulus [1]. In general, significant conditioning is lost after 2-6 weeks of insufficient training. In other words, the individual becomes ‘less fit’ [2]. Therefore, recognizes that stopped, or reduction of a training stimulus leads to a decline in specific conditioning. The rate of ‘fitness’ decrement with training cessation does vary from one physiological parameter to the another and so are here divided logically. The most important parameters that are affected from reduce training or detraining is maximal oxygen uptake (VO2max), anaerobic or lactate threshold and running economy. Therefore, the purpose of this study was to investigate the effects of reduce training on cardiovascular parameters in distance runners.

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A Case Report of Coarctation of Aorta Presenting as ST Elevation in Anterior Chest Leads of ECG with Severe Left Sided Neck Pain_ Crimson Publishers

 A Case Report of Coarctation of Aorta Presenting as ST Elevation in Anterior Chest Leads of ECG with Severe Left Sided Neck Pain by Hammad S* in Open Journal of Cardiology & Heart Diseases_ journal of cardiology & heart diseases

 

Abstract
Coarctation of aorta is characterized by narrowing of the aortic lumen. Complex lesion are complicated by associated cardiac anomalies and picked in infancy while simple coarctations are not diagnosed until adulthood when it manifests as secondary hypertension or its complications. We are reporting a case of severe coarctation of aorta which presented as ST elevation on anterior chest leads with severe sudden onset left sided neck pain mimicking anterior wall myocardial infarction and patient was thrombolysed due to dynamic ECG changes and new onset severe left sided neck pain. Clinicians and cardiologists worldwide should be aware of such occurrence to prevent unnecessary thrombolysis in patients not fullfiling other criteria of myocardial infarction. Bedside echo assessment and highly sensitive cardiac troponin and inflammatory markers (hs-CRP) could help in correctly aiding to diagnosis and preventing such occurrences from happening which can complicate into life threating hemorrhage

https://crimsonpublishers.com/ojchd/fulltext/OJCHD.000550.php

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Brain Parenchyma to Repair Spinal Cord Deficits_ Crimson Publishers

 Brain Parenchyma to Repair Spinal Cord Deficits by Abbas Alnaji* in Techniques in Neurosurgery & Neurology_ Techniques in Neurosurgery & Neurology

Abstract
Decades of spinal cord repair efforts had been crowned by stem cells SC role as a very recent promising scientific prospect. Many and a lot of work all over the world used SC in very different ways and techniques to overcome the damage in spinal cord whether morbid or traumatic unfortunately until the date without yield. They used SC from placental/umbilical cord, bone marrow, perhaps blood components and recently the adipose tissue. I intended to use adipose tissue derived SC to treat a 70 years old man with a tetraplegia of 30 years due to a road traffic accident cervical 6 vertebral fracture. At the time of case discussion with the patient and his family my plan was to MRI imaging, to see the basic structural damage and to reveal any improvements after SC use, the MRI showed huge neural canal narrowing at the C6 due to fractured vertebral hypertrophy over these 30 years with adjacent inferior syrinx the case necessitated a laminectomy decompression with syrinx opening. The other factor in family discussion was the tissue biopsy for detection of any intracellular bacteria by molecular study as screen for unknown which was developed in a molecular biology lab. As I am increasing my knowledge in adipose tissue manipulation for being as SC, I realized that better if we can use brain tissue instead. Why brain tissue in a time it is highly differentiated and from where to take, do we want to build a place and spoil the other!! In some of my writings I mentioned the huge capability of brain to repair itself whatever the age and the damage is/ are just if we free its cells from the intracellular bacteria which I find in the biopsies I take in different diseases one of them is the cerebral palsy due to any cause standardly mentioned

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