Can we Optimize Immune Checkpoint Inhibitors Efficacy in Digestive Oncology?: Crimson Publishers

Can we Optimize Immune Checkpoint Inhibitors Efficacy in Digestive Oncology? by Anthony Lopez* in Crimson Publishers: Crimson research

Immunotherapy is revolutionizing oncology, with a simple guiding principle: the host immune system has the potential to eradicate cancer, treatment consisting in optimizing immune actors' functions. Although significant results were demonstrated in patients with melanoma or lung cancer, objective response rate (ORR) is only 20% in digestive oncology. However, we can improve this situation by a better knowledge of anti-tumor immunity. For example, ORR is multiplied by two to three in case of PD-L1 (programmed death-ligand 1) overexpression or microsatellite instability (MSI). In a near future, we will certainly be able to take into account other biomarkers for building composite scores for assigning to each patient with digestive cancer an 'immune identity card' able to strongly predict immunotherapy efficacy.

Gastroenterology Medicine & Research: Crimson Publishers

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https://www.crimsonpublishers.com/gmr/fulltext/GMR.000508.php

Gastroenterology: Medicine & Research ((GMR) ISSN : 2637-7632, Impact Factor : 0.668)

Celiac Disease and "Idiopathic" Portal Hypertension: A Case Report and Review of Literature - Crimson Publishers

 

Celiac Disease and "Idiopathic" PortalHypertension: A Case Report and Review of Literature by Khaled Matar in Gastroenterology: Medicine & Research

Idiopathic Portal hypertension (IPH) is a disorder of unknown etiology. We are reporting a case of IPH and Celiac disease. A 39-year old female patient was referred to gastroenterology clinic for diagnostic work-up of severe pancytopenia, massive splenomegaly and tense ascites. Diagnosis of IPH was clinically suspected after exclusion of possible causes that can manifest as portal hypertension. Endoscopy revealed esophageal varices along with atrophic folds and scalloping in the second part of the duodenum. Celiac disease was diagnosed based on histopathology findings and strong serology positivity for anti- tissue transglutaminase IgA. Her symptoms improved on a gluten-free diet and laboratory tests results improved considerably with significant reduction of the spleen size and ascites.

https://crimsonpublishers.com/gmr/fulltext/GMR.000504.ph