The Next Nobel Prize Must Go to the Eminent Tom Spears - Crimson Publishers

The Next Nobel Prize Must Go to the Eminent Tom Spears by Sam Yosemite* in Significances of Bioengineering & Biosciences

One of the most inspiring stories in modern applied science begins in the hopeless concrete barrios of a Toronto neighborhood called Lawrence Park - and ends in triumph. It is the story of how a young bioengineer overcame deprivation and prejudice to establish himself as a global leader in two fields not usually conjoined: bioengineering and chemistry. Spears, who today is a youthful 53, has established the modern understanding that the engineering of living systems - bioengineering -owes much to chemistry at its tiniest level, the actions of molecules, atoms and their components. This is fundamental to all that we know of movement today: the United States military and DARPA are currently building new flying vehicles using the Spearsian analysis of the biomechanics of the Sauridae family of South America (in particular the relationship between the primary flight feathers and hocks.

https://crimsonpublishers.com/sbb/fulltext/SBB.000512.php 

An Engineering Approach to the Scientific Method_International Journal of Research in BioSciences_Crimson Publishers

An Engineering Approach to the Scientific Method by Dale Feldman*in Significances of Bioengineering & Biosciences

Part of the primary motto of this journal is to provide engineering approaches to enhance the power of the scientific method. The engineering approach is essentially the engineering design process. The scientific method is similar but is hypothesis driven vs. design driven. In the scientific method a hypothesis is generated as a potential answer to an important question. An experiment is tested to prove or disprove the hypotheses. The results of the experiment are discussed in the context of the original question and whether the hypothesis was proven or not. The results are also compared to other studies looking at the same or similar questions. Therefore the study is looked at whether it follows from previous studies, what are the ramifications of the results related to the original question, and what needs to be examined next; further test the hypothesis or test a different hypothesis. 
http://crimsonpublishers.com/sbb/fulltext/SBB.000501.php

A Twist in the Tale: TWIST1-SOX2 Axis Governs ABCG2-Mediated Paclitaxel Resistance of Breast Cancer Stem Cells - Crimson Publishers

A Twist in the Tale: TWIST1-SOX2 Axis Governs ABCG2-Mediated Paclitaxel Resistance of Breast Cancer Stem Cells by Pritha Mukherjee and Urmi Chatterji* in Significances of Bioengineering &Biosciences

Epithelial-mesenchymal transition (EMT) is an important process during development by which epithelial cellsb acquire mesenchymal, fibroblastlike properties and show reduced intercellular adhesion and increased motility.The identification of epithelial-mesenchymal plasticity of breast cancer stem cells provided another level of complexity regarding development of strategies to eliminate these lethal seeds of breast cancer. In determining the association between Sox2, cell migration and expression of EMT markers, we found a persistently high expression of Twist1 and its apparent lack of EMT-like properties during migratory arrest of MDA-MB-231 cells, even after paclitaxel treatment of Sox2-silenced cells. The role of Sox2-dependent Twist1 in maintaining stemness was more prominent when Sox2 expression was high in brCSCs. It can be presumed now that Twist1 expression in presence or absence of Sox2 defines the precise mechanism underlying the possible role of Twist1 in crossroads of pluripotency and EMT of breast cancer stem cells.

http://crimsonpublishers.com/sbb/fulltext/SBB.000532.php