Intestinal Microbiota and Its Link with Mind and Heart_ Crimson Publishers

 Intestinal Microbiota and Its Link with Mind and Heart by Álvaro Zamudio Tiburcio* in Gastroenterology Medicine & Research_ Gastroenterology Medicine & Research

Abstract
A mini review about how the Intestinal Microbiota (IM) is linked to the mind and heart is carried out. It is pointed out how once IM inflammation (Dysbiosis) generated, a series of mechanisms, immunological, neuronal and endocrine, that affect host phenotypes are triggered. The interpretation of what the gutmicrobiota- brain axis is deepened. (GBA), and it is exemplified how, through bidirectional communications with the Intestinal Microbiota, a series of changes, which impact human health, are translated. Likewise, 10 conclusions are proposed on diverse topics, because the IM not only relates to the mind-heart binomial, but it has to do with many organs and consequently with many sufferings

Commentary
Today, various functions that the Microbiota exerts have been better understood; Above all, the Intestinal Microbiota, since this is the most significant of the Microbiota, because it represents the highest percentage of it. It´s in the intestine, especially in the colon, where the IM lives, and where a series of conversations take place, where microorganisms and environmental antigens interact with the host and, translate, the magnificent functions of this super-organ. Among these functions are protection, against pathogens, metabolic reactions, stimulation of immunological processes, homeostasis, the collection of ingested energy, the generation of vitamins, among many others [1]. IM not only links with the mind, it also does it with the heart, through signals similar to those produced by hormones, by affecting the host’s metabolic phenotypes. There are also direct impacts of metabolites on the development of thrombosis. Finally, some Acids Short chain fats, produced in the microbial fermentation of complex carbohydrates, may increase the risk of vascular brain disease [2-4].

It has been reported that antibiotic-generated dysbiosis stimulates the release of cytokines, which aggravate the cardiac lesion, in rats, with major ischemia and myocardial re-perfusion [5]. To understand all of the above, we must go where all these transmissions are generated. That place is called the gut-microbiota-brain axis. There are interactive and parallel channels that communicate the intestinal microbiota with the brain. These channels are both endocrine, neuronal and immunological and, the brain, through the Autonomous Nervous System, interacts in the intestinal secretion, its transit; its motility, as well as its permeability, translating diverse manifestations of the genome of the microorganisms, existing there. All this communication is a circuit, where there will be clinical manifestations, depending on the place of involvement [6]. In other way, gastrointestinal and psychiatric conditions are associated with GBA e, influenced by environmental and genetic factors. Due to the above, the challenge of the next generation is to detect, why and in what part of this transmission, there is an affectation; Once this problem is elucidated, the cure of both mental and gastrointestinal diseases will be closer [7]. Now, how does the effects of certain medications alter the intestinal microbiota, and consequently, its impact on health?

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