A Strange Association Between A Rectum- Infiltrating / Metastatic Dedifferentiated Chordoma And Schmidt’s Syndrome by Teresa Staiano* in Novel Approaches in Cancer Study_ Journal of Cancer Research
Abstract
A 57-year-old Caucasian woman, presented to our
Endoscopy Unit, complaining several episodes of rectal bleeding during the last
2 weeks, associated with lower abdominal and back pain, mild weight loss and
asthenia. On presentation, the patient was hemodynamically stable. Her
laboratory tests showed normocytic anemia of 10g/dL, increase of creatine chinase of 264U/L, and mild
hypopotassemia (3.4 mEq/l). Moreover, she reported a family history for gastric
cancer (father), and she was surveilled by our Oncological center for a
recurrent neoplastic disease and for a systemic autoimmune disease, for many
years stable under treatment with cycles of radiotherapy, imatinib mesylate,
steroids, levothyroxine, and semestral zoledronic acid. After she underwent
flexible sigmoidoscopy, a bulky ulcerated rectal mass, of suspected extraparietal origin, was
revealed in (Figure 1) and (Figure 2). Multiple random biopsies were obtained
from the normal mucosa as well as separately from the ulcers
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