Monitoring Cardiovascular Disease Progression_ Crimson Publishers

Monitoring Cardiovascular Disease Progression by Jay N Cohn* in Open Journal of Cardiology & Heart Diseases_ journal of cardiology & heart diseases

Abstract

Cardiovascular disease management guidelines and therapeutic trials are traditionally driven by efforts to reduce morbid events over a finite period of time, often the 10-year outcome that forms the basis for most algorithms aimed at defining risk [1,2]. This relatively short interval in a person’s life mandates that trials focus on advanced disease with high shortterm morbidity that will make it possible to identify a favorable effect of an intervention. This restriction makes it impractical to study early disease, when an intervention might be dramatically effective in prolonging life but will have too few morbid events over 5 or 10-year period of time to demonstrate effectiveness of therapy.

A proposed solution to this problem is to aim therapy not exclusively at morbidity reduction but rather at disease progression which should be a forerunner of morbid events. We have been utilizing a non-invasive evaluation program in our centers in Minneapolis, MN and Sarasota, FL over the past 20 years (Minneapolis) and 10 years (Sarasota) in order to identify early disease in need of treatment and to track disease severity to monitor progression. Our experience has convinced us that early vascular or cardiac disease detection is of great value in detecting, monitoring and treating cardiovascular disease

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Dermoid Cyst of the Conus Medullaris in Adult: A Case Report and Review of the Literature_ Crimson Publishers

 Dermoid Cyst of the Conus Medullaris in Adult: A Case Report and Review of the Literature by Lakhdar F* in Techniques in Neurosurgery & Neurology_ Journal of Neurosurgery

Abstract

Background: Intramedullary dermoid cyst is a type of rare congenital intraspinal lesions especially those located in the conus medullaris and not associated with spinal dysraphism. The Management of DC is especially difficult in eloquent areas such as the conus medullaris, with tendency to recurrence and poorly respond to oncologic treatment.

Objective: We aim to provide a summary of the pathology, clinical presentation, and management strategies of dermoid cysts involving the conus medullaris with review of the literature.

Case presentation: A 37-year-old woman presented with progressive low back pain and loss of bowel and bladder function. His magnetic resonance imaging (MRI) scan showed a heterogeneous tumor with tethering of the spinal cord. He was taken for a midline myelotomy that drained yellowish keratinous fluid and decompressed the cyst. No aggressive attempt at complete resection of the cyst wall was undertaken. She made a complete recovery after surgery with complete resolution of her symptoms.

Conclusion: Dermoid cyst of the conus medullaris without any congenital spinal dysraphism make this case unique. Surgical control and restraint are the key for optimal management and good recovery

https://crimsonpublishers.com/tnn/fulltext/TNN.000562.php

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