Monitoring Cardiovascular Disease Progression_ Crimson Publishers

Monitoring Cardiovascular Disease Progression by Jay N Cohn* in Open Journal of Cardiology & Heart Diseases_ journal of cardiology & heart diseases

Abstract

Cardiovascular disease management guidelines and therapeutic trials are traditionally driven by efforts to reduce morbid events over a finite period of time, often the 10-year outcome that forms the basis for most algorithms aimed at defining risk [1,2]. This relatively short interval in a person’s life mandates that trials focus on advanced disease with high shortterm morbidity that will make it possible to identify a favorable effect of an intervention. This restriction makes it impractical to study early disease, when an intervention might be dramatically effective in prolonging life but will have too few morbid events over 5 or 10-year period of time to demonstrate effectiveness of therapy.

A proposed solution to this problem is to aim therapy not exclusively at morbidity reduction but rather at disease progression which should be a forerunner of morbid events. We have been utilizing a non-invasive evaluation program in our centers in Minneapolis, MN and Sarasota, FL over the past 20 years (Minneapolis) and 10 years (Sarasota) in order to identify early disease in need of treatment and to track disease severity to monitor progression. Our experience has convinced us that early vascular or cardiac disease detection is of great value in detecting, monitoring and treating cardiovascular disease

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