T cell Immune Pathways Current and Future Implementation in
Cancer Immunotherapy by Reham M El Shabrawy* in
Novel Approaches in Cancer Study_ Journal of Cancer Research
Abstract
T cells are central players in cancer immune response. The discovery of T
cell immune pathways has revealed several inhibitory and stimulatory pathways
that affect the differentiation and activation of T cell. Theses pathways
represent ideal candidates that can be targeted to augment in-vivo. T cell immune
response against tumors. In this mini review we will try to reveal some
inhibitory and stimulatory T cell immune pathways to which efforts of those
interested in cancer immunotherapy can be directed.
Background
Tumor immunotherapy exceeds radiotherapy and chemotherapy in the fact that
it considered the most tumor-specific therapy; it is characteristically
effective in metastatic tumors,
which is a real challenge facing current tumor therapies. Additionally, it
confers long-lasting memory, which cannot by induce by other therapeutic
approaches. T cell is the major cell orchestrating the anti-tumor immune
response. For a T cell to be activated and differentiated, it should receive
activating signal not only from the T cell receptor but also from other
co-stimulatory molecules. On the other hand, to maintain a balanced immune system other molecule are
involved in the inhibition of the activated T cell after the end of an immune
response. Understanding these pathways can help in influencing the activity of
T cell and thus provide other options for cancer immunotherapy.
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