Bones, Arthritis and the Body’s Water-Some Practical Suggestions: Crimson Publishers

Bones, Arthritis and the Body’s Water-Some Practical Suggestions by Maria Kuman* in Crimson Publishers: Bone Marrow Research

Our body is mostly water. How this relates to bones and arthritis? Speaking about the amount of water in the body, we should acknowledge its decline with aging. According to Russian studies [1], the amount of water in the fetus is 95%, in the baby- 92%, and it constantly decreases. Between age 20 and 30 the amount of water in the body is 70%, between age 40 and 50 it is 50% (this is when the wrinkles appear). After the age of 70, the amount of water in the body drops down to 30%. This is when the bones become brittle because there is no enough water in them to keep them elastic [1].

The bones have tiny canals filled with structured water. This keeps the bones elastic. When after the age of 70 the amount of water in the body (including bones) drops down to 30%, the bones become brittle. That is why it is so dangerous for the elderly to fall because the chances to break a bone at the fall are high. Hormones rule the amount of water in the body. With the aging as the number of hormones decline, and so does the amount of water in the body. How does arthritis relate to water? Arthritis is more frequent among elderly when the amount of water in the body decreases, but the toxins deposited in the joints play a major role in arthritis

https://crimsonpublishers.com/rabs/fulltext/RABS.000510.php

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A Secreted Protein in the Wnt Signaling Pathway-R-Spondin3: A Mini-Review_Crimson Publishers

Secreted Protein in the Wnt Signaling Pathway-R-Spondin3: A Mini-Review by Qing Yang in Significances of Bioengineering & Biosciences: Crimson Publishers_American Journal of Bioscience and Bioengineering

R-spondins (Roof plate-specific Spondins, RSPOs) are secreted proteins, which act as activators of Wnt/β-catenin signaling and play roles in cell proliferation and differentiation, embryonic development, vasculogenesis as well as many human diseases. R-spondin3 (RSPO3) is a member of RSPOs family, containing two adjacent cysteine-rich furin-like domains, which act as an agonist in Wnt signaling. In this mini-review, we discuss and classify recent progress in understanding the protein functions of RSPO3 in embryonic development, vasculogenesis, and its role in cancers.

https://crimsonpublishers.com/sbb/fulltext/SBB.000518.php

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PEX12 Novel Mutation: A Case Report on Iranian Girl with Childhood Onset Peroxisomal Disorder: Pseudo ALD?: Crimson Publishers

PEX12 Novel Mutation: A Case Report on Iranian Girl with Childhood Onset Peroxisomal Disorder: Pseudo ALD? by Tabarestani S in Research in Pediatrics & Neonatology: Peroxisomal Disorder

Objective: To report a 7 years old girl with genetic and biochemical characteristics of zellweger spectrum disorder who presented with phenotype and neuro imaging findings of adrenoleukodystrophy.

Methods: Target gene sequencing was performed by using a custom designed panel for this patient with focused mutation analysis on 16 peroxisomal genes included in the panel. Sanger sequencing was used to confirm the identified mutation.

Results: This patient was homozygote for a missense mutation in exon 2 of the PEX 12 gene; c.541T>G (p.Tyr181Asp) which is a conserved residue in the N-terminal region crucial for localization to peroxisomes. Her parents and healthy sister were also found to have the same heterozygote mutation.

Conclusion: We suggest that PEX 12 gene mutations with a milder phenotype may be a potential candidate for posterior dominant leukodystrophy of childhood resembling X-linked ALD. This is entitled to pseudo- ALD and may be a diagnostic possibility in patients who develop ALD phenotype and neuroimaging particularly, in girls.

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Decompression Haematuria from Upper Urinary Tract: A Rare Complication_Crimson Publishers

Decompression Haematuria from Upper Urinary Tract: A Rare Complication by
Praveen Pushkar* in Experimental Techniques in Urology & Nephrology: Crimson Publishers_Asian Journal of Urology

In cases of chronic urinary retention, post decompression diuresis and haematuria are well known complications. Majority of cases of decompression haematuria resolves spontaneously. Rarely haematuria is so much that blood transfusion is required. In all the cases reported in literature haematuria occurs as generalized oozing from bladder mucosa after decompression. In the case described below there was isolated bleeding from both renal pelvis rather than bladder mucosa which resulted in obstructive renal failure.

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A Secreted Protein in the Wnt Signaling Pathway-R-Spondin3: A Mini-Review_Crimson Publishers

Secreted Protein in the Wnt Signaling Pathway-R-Spondin3: A Mini-Review by Qing Yang in Significances of Bioengineering & Biosciences: Crimson Publishers_American Journal of Bioscience and Bioengineering

R-spondins (Roof plate-specific Spondins, RSPOs) are secreted proteins, which act as activators of Wnt/β-catenin signaling and play roles in cell proliferation and differentiation, embryonic development, vasculogenesis as well as many human diseases. R-spondin3 (RSPO3) is a member of RSPOs family, containing two adjacent cysteine-rich furin-like domains, which act as an agonist in Wnt signaling. In this mini-review, we discuss and classify recent progress in understanding the protein functions of RSPO3 in embryonic development, vasculogenesis, and its role in cancers.

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Macular Abnormality after Successful Surgery for Idiopathic Macular Hole Assessed Using Optical Coherence Tomography | Crimson Publishers

Macular Abnormality after Successful Surgery for Idiopathic Macular Hole Assessed Using Optical Coherence Tomography by Nazimul Hussain in Medical & Surgical Ophthalmology Research

Purpose: Macular changes following Internal Limiting Membrane peeling after successful Macular hole closure using optical coherence tomography.

Methods: 5 eyes of 5 patients were included in the study. The inclusion criteria were idiopathic full thickness macular hole and completed at least 6 months follow up. All patients underwent optical coherence tomography assessment before and after surgery until 6 months. Macular thickness and morphology map was analyzed before and after surgery.

Results: There were 3 males and 2 females. The age range from 45 to 59 years. Conspicuous irregular surface of the inner retina on Optical Coherence Tomography surface topography was evident in all eyes at 6 months. This was also associated with downward slope of the temporal macula seen on surface topography. There was trend towards decrease in subfield thickness especially in the T1, S1, I1 and N1 6 months after surgery. The average decrease was -60.4 microns in T1, -20.4 microns in S1, -13.0 microns in I1 and -23.4 microns in N1.

Conclusion: In this small case series brilliant blue assisted ILM peeling after successful macular whole closure showed evidence of decrease in macular thickness in all first subfield quadrant and downward slope of the temporal macula as well as conspicuous irregularity of the inner retina.

https://crimsonpublishers.com/msor/fulltext/MSOR.000517.php

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Complete Khoya Replacement in Mango Burfi to Increase Shelf Life: A Case Study: The Journal of Poultry Science: Crimson Publishers

Complete Khoya Replacement in Mango Burfi to Increase Shelf Life: A Case Study by Smita Lele*, Tripti Pandey and Shanooba PM in Crimson Publishers: The Journal of Poultry Science

Khoya is a heat coagulated partially dehydrated whole milk product obtained by heating, evaporation & desiccation at atmospheric pressure. The main reaction in the preparation of khoya is the heat denaturation and coagulation of milk proteins. Most of the albumins & globulins are rapidly denatured, the protective properties of the other colloids are destroyed during boiling and the process is accelerated by incorporation of air seen as frothing by constant stirring or container rotation. Albumin and globulins are coagulated below 100 °C, while casein is coagulated above 100 °C. The factors that influence the heat coagulation are temperature and hold up time, concentration of casein, acidity of milk and salt balance [1].

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Ageing and Health Services Use in Israel- Crimson Publishers

Ageing and Health Services Use in Israel by Ariela Lowenstein in Health Services

Israel, as many other countries, must cope with issues that arise from demographic changes that are expressed both in the size and composition of the population. One of the prominent changes is in the age-structure of the society, which is especially influenced by the ageing of the population. Israel's population consists of 12.8% Jewish elders and 4.4% Arab elders. However, the proportion of disabled Jewish elders is 16% compared with 31% among Arab elders [1]. Disability leads to loss of independence, increases consumption of health services, and raises the cost of medical treatments. Among minorities, lower rates in Health Services use were found, since cultural differences are often not considered. Lack of sensitivity towards minority needs may lead to a gap between potential consumers and existing services [2-6].

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