Secreted
Protein in the Wnt Signaling Pathway-R-Spondin3: A Mini-Review by Qing Yang in Significances of
Bioengineering & Biosciences: Crimson Publishers_American Journal of Bioscience and Bioengineering
R-spondins (Roof plate-specific Spondins, RSPOs) are secreted proteins,
which act as activators of Wnt/β-catenin signaling and play roles in cell
proliferation and differentiation, embryonic development, vasculogenesis as
well as many human diseases. R-spondin3 (RSPO3) is a member of RSPOs family,
containing two adjacent cysteine-rich furin-like domains, which act as an
agonist in Wnt signaling. In this mini-review, we discuss and classify recent
progress in understanding the protein functions of RSPO3 in embryonic
development, vasculogenesis, and its role in cancers.
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