Cellular and Molecular Medicine Approaches to Therapy-Crimson Publishers

Cellular and Molecular Medicine Approaches to Therapy by Gundu HR Rao in Developments in Clinical & Medical Pathology

Inflammation seems to be the major initiator of many processes that leads to self-healing as well as pathogenesis of major metabolic diseases, including, atherosclerosis, obesity, metabolic syndrome, type-2 diabetes, ischemic heart disease and stroke. Inflammation seems to play a role even in acute events such as vulnerable plaque rupture, precipitation of some of the events associated with stroke, advance events in cancer and neuronal pathology. In spite of the fact that researchers have attributed such an important role for inflammation, there are hardly any drugs that specifically work on this process. When it comes to anti-ageing, there are just two drugs in the market. Although numerous compounds have been introduced as antioxidants, no major success has been reported in any randomized clinical studies.

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https://crimsonpublishers.com/dcmp/fulltext/DCMP.000511.php

Evaluation of Salmonella Species in Water Sources in Two Local Government Areas of Anambra State-Crimson Publishers

Evaluation of Salmonella Species in Water Sources in  Two Local Government Areas of Anambra State by Ekelozie Ifeoma Stella in Cohesive Journal of Microbiology & Infectious Disease

Microbial quality of water using Salmonella species in water sources was investigated in two Local Government Areas in Anambra State, between the months of September and December, 2013. A total of 220 water samples were analyzed using Bacteriological Analytic method and membrane filtration method. Antimicrobial Susceptibility test by disc diffusion method and serotyping was done using slide agglutination methods with polyvalent antiserum. Salmonella species was most prevalent (35.0%) in Reservoir water samples and least prevalent (7.45) in Borehole-water samples examined.  

https://crimsonpublishers.com/cjmi/fulltext/CJMI.000501.php

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Desmoplastic Non-Infantile Ganglioglioma; An Incidental Finding with Unusual Localization-Crimson Publishers

Desmoplastic Non-Infantile Ganglioglioma; AnIncidental Finding with Unusual Localization by
Dimitrios Kanakis in Techniques in Neurosurgery & Neurology

Desmoplastic non-infantile ganglioglioma (DNIG) is a rare tumor entity and only a small number of cases have been published until now in the literature. Although its infantile counterpart (desmoplastic infantile ganglioglioma [DIG]) has been already recognized and included together with desmoplastic infantile astrocytoma (DIA) in the WHO Classification of CNS tumors, DNIG has not been accepted as a distinct tumor entity. The reason for this is obviously the scarcity of the neoplasm and subsequently the absence of substantial information regarding its pathogenesis and its association to the infantile form. Herein we present an interesting case with an unremarkable clinical presentation, which came to medical attention after the performance of imaging investigations, for staging purposes of a multifocal papillary thyroid carcinoma. Although the tumor showed the typical biphasic nature, consisting of a solid and a cystic component, its localization in the left ventricular trigonum, was indeed uncommon. Finally, both the histomorphological and the immunohistochemical findings were consistent with the diagnosis of a desmoplastic non-infantile gangioglioma. The occurrence of DNIG with the various clinical manifestations as well as the diverse imaging features, underlines the need of histopathological examination, in order to establish the final diagnosis.

https://crimsonpublishers.com/tnn/fulltext/TNN.000502.php

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Preliminary phytochemical analysis and in vivo evaluation of antipyretic effects of methanolicextract of Argyreia pilosa Wight & Arn: Crimson Publishers

Preliminary phytochemical analysis and in vivo evaluation of antipyretic effects of methanolicextract of Argyreia pilosa Wight & Arn by DSNBK Prasanth*, Atla Srinivasa Rao and Rajendra Prasad Yejella in Journal of Alternative and Complementary Medicine

The antipyrexia action of the methanol extract of A. pilosa had been explored utilizing the yeast evoked pyrexia procedure in rabbits. Paracetamol utilized as a positive control as well as negative control group acquired distilled water. Rectal temperatures of all rabbits had been documented instantly prior to the administration of the extract or vehicle or paracetamol as well as again at 30min period for 3h utilizing digital thermometer. The extract had been additionally phytochemically tested with regard to alkaloids, tannins, saponins, flavonoids, cardiac glycosides and phenols. At 400mg/kg dosage the extract revealed considerable decrease in yeast evoked raised temperature when compared with that of standard drug paracetamol where by the extract dose 200mg/kg had been less effective as compared to higher dose (p<0.05). Phytochemical testing demonstrated the existence of flavonoids, alkaloids, tannins, phenols, steroids, acid compounds, glycosides, amino acids, and proteins. This research confirmed that this methanol extract of A. pilosa at a dose of 400mg/kg owns considerable antipyretic outcome against the yeast-induced raised temperature. The antipyretic activity of A. pilosa extract could be due to its secondary metabolites, which probably consist of flavonoids like Rutin and Quercetin; sterols like β-Sitosterol. But, further phytochemical, as well as biological tests, are recommended to determine the other active chemical constituents accountable for the antipyretic activity.

https://crimsonpublishers.com/acam/fulltext/ACAM.000510.php

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