Preliminary phytochemical analysis and in vivo evaluation of antipyretic effects of methanolicextract of Argyreia pilosa Wight & Arn: Crimson Publishers

Preliminary phytochemical analysis and in vivo evaluation of antipyretic effects of methanolicextract of Argyreia pilosa Wight & Arn by DSNBK Prasanth*, Atla Srinivasa Rao and Rajendra Prasad Yejella in Journal of Alternative and Complementary Medicine

The antipyrexia action of the methanol extract of A. pilosa had been explored utilizing the yeast evoked pyrexia procedure in rabbits. Paracetamol utilized as a positive control as well as negative control group acquired distilled water. Rectal temperatures of all rabbits had been documented instantly prior to the administration of the extract or vehicle or paracetamol as well as again at 30min period for 3h utilizing digital thermometer. The extract had been additionally phytochemically tested with regard to alkaloids, tannins, saponins, flavonoids, cardiac glycosides and phenols. At 400mg/kg dosage the extract revealed considerable decrease in yeast evoked raised temperature when compared with that of standard drug paracetamol where by the extract dose 200mg/kg had been less effective as compared to higher dose (p<0.05). Phytochemical testing demonstrated the existence of flavonoids, alkaloids, tannins, phenols, steroids, acid compounds, glycosides, amino acids, and proteins. This research confirmed that this methanol extract of A. pilosa at a dose of 400mg/kg owns considerable antipyretic outcome against the yeast-induced raised temperature. The antipyretic activity of A. pilosa extract could be due to its secondary metabolites, which probably consist of flavonoids like Rutin and Quercetin; sterols like β-Sitosterol. But, further phytochemical, as well as biological tests, are recommended to determine the other active chemical constituents accountable for the antipyretic activity.

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