Combined Photodynamic and Radiotherapy Synergistic Effect in Cancer Treatment_ Crimson Publishers

Combined Photodynamic and Radiotherapy Synergistic Effect in Cancer Treatment by Fatma Yurt in Novel Approaches in Cancer Study

Photodynamic therapy (PDT) is a noninvasive method in cancer treatment. Nowadays, it has been used in clinical successfully to the treatment of skin, esophagus and lung cancer [1-3]. PDT occurs which a certain wavelength light is excited the photosensitizer (PS). As a result of this photo-excitation, reactive single oxygen (ROS) species form locally and cause cancer cell death [4-7]. When applied the light to PS is excitedfrom ground state to short live singlet state and then converted triplet state with long live. Triplet state of PS can produce ROS via two different photochemical reactions; type I and type II. In Type I PS in the triplet state reacts with water or biomolecules and then generated free radicals, superoxides and peroxides. In type II, singlet oxygen which is very reactive occurs from reaction the triplet state and molecular oxygen in the tissue oxygen.

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