How Can We Optimize the Granulose Cell Function of Oocytes from an Endometriosis Patient to Improve the Reproductive Outcomes-A Short Communication?_ Crimson Publishers

How Can We Optimize the Granulose Cell Function of Oocytes from an Endometriosis Patient to Improve the Reproductive Outcomes-A Short Communication? by Kulvinder Kochar Kaur* in Perceptions in Reproductive Medicine_ Journal of Reproductive Health

 

Abstract
Endometriosis, results in infertility in 50% infertile women. Explanations given are poor oocyte quality as well as low grade embryos associated with abnormal folliculogenesis, with reduced chances of fertilization correlated with enhanced oxidative stress, high reactive oxygen species (ROS) levels/local inflammation. Particularly escalated amounts of cytokines are found in follicular fluid of follicles of Endometriosis subjects. Here we further detail on the work going on in finding the role of granulosa cells in Endometriosis subjects with regards to increased inflammation, alteration in cytokines in follicular fluid that associates with follicular fluid in causing the oxidative stress, and how the upstream pathway involving tumour necrosis factor alpha (TNFα) and nuclear factor kappa B( NFκB) that influences both telomere length as well as telomerase activity, with shorter telomeres as well as reduced telomerase activity associated with aging follicles as well as those observed in patients with premature ovarian insufficiency (POI). Thus, this enhanced granulosa cell NFκB corresponds with inflammation found in FF along with effect on telomeres. Ways of targeting it seems to be one answer in improving reproductive potential of Endometriosis patients.

https://crimsonpublishers.com/prm/fulltext/PRM.000570.php

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Kaftar Kouh of Ferdous, Comprehensive Evidence of Paleolithic Population in Southern Khorasan, Iran_ Crimson Publishers

Kaftar Kouh of Ferdous, Comprehensive Evidence of Paleolithic Population in Southern Khorasan, Iran by Ali Sadraei* in Archaeology & Anthropology:Open Access_ American Journal of Archaeology

Abstract

The eastern part of Iran, especially Khorasan, has remained in a completely unclear and vague state in spite of the fact that Paleolithic studies have been the pioneer of archeological research. In the meanwhile, the condition of the lower Paleolithic period is wretchedly worse, so that the only evidence of this period is that obtained of two widely-cited sites, namely Kashfroud and Daroungar River(Artian); while in other parts of Khorasan no evidence indicating the presence of Pleistocene hominin populations has been published to this date, which is largely questionable and requires a revise on the archaeology of the Paleolithic era in this part of Iran.

Kaftar Kkouh site of Ferdous is among the latest Paleolithic evidence found in southern Khorasan, located in the southeastern part of Ferdous, 2km from the city of Ferdous, on the hills overlooking Ferdous Plain. From among the Lithic artifact obtained from these two sites, Bifacial chopper-core, Unifacial choppercore, radial cores, crude flakes, and Levallois that according to the knapping type and technique used are likely to be attributed to the late lower Paleolithic era and the early Middle Paleolithic period. In the present paper, the authors seek to provide a relative chronology for these devices in addition to their morphology, and compare them with the surrounding Paleolithic sites such as Kashfroud, Daroungar, etc

https://crimsonpublishers.com/aaoa/fulltext/AAOA.000574.php

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