Hitting the Bullseye: Are Cell Penetrating
Peptides (CPP) the Future of Targeted Cancer Therapy? by Keith S Robinson in
Novel Approaches in Cancer Study
Cancer treatments have
traditionally entailed system wide toxicity with debilitating side effects for
the patient. The demand for targeted therapies is clearly exhibited in the
pipeline of large pharmaceuticals where the need to identify delivery vehicles
that offer the prospects of more targeted, efficacious treatments with fewer
side effects is paramount. Historically a number of technologies have been
tried and tested including antibody drug conjugates, nanoparticles, cell
surface markers and targeting the tumor microenvironment. Unfortunately, these
approaches have often had lackluster results and created alternative toxic
profiles, such as immune activation. Interest in an historic technology, cell
penetrating peptides (CPPs), has been recently reinvigorated, presenting the
opportunity to deliver targeted, biologically active cargoes to cancerous cells
for treatment without systemic side effects.
https://crimsonpublishers.com/nacs/fulltext/NACS.000531.php
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