NSAIDs - Associated Damage to the Stomach Mucosa (Experimental Study)_ Crimson Publishers

 NSAIDs - Associated Damage to the Stomach Mucosa (Experimental Study) by Trubitsyna IE* in Gastroenterology Medicine & Research_ Gastroenterology Open Access Journals

 

Abstract
NSAIDs remain dangerous drugs due to the damaging effect on the mucous membrane of the stomach, intestines. Experimental studies were conducted to study the damaging effects of nimesulide and lornoxicam. It was found that these drugs damage the mucous membrane of the stomach. a non-selective drug has a slightly greater damaging effect. The damaging effect of these drugs enhances motor impairment, a decrease in pH, and an increase in secretion volume. NSAIDs often lead to the formation of acute ulcers of the gastrointestinal mucosa. The development of NSAID-associated ulcerative lesions is due to an imbalance between the factors of defense and aggression in Summary non-steroidal anti-inflammatory drugs Summary nonsteroidal anti-inflammatory drugs the mucous membrane of the gastrointestinal tract [1,2]. AIM of our research was to establish factors that contribute to the development of NSAID associated ulcerative lesions of the gastric mucosa.

Material and Methods
The experiments were carried out on white Wistar rats of both sexes, weighing 190-210g. Before the operation, food was taken away for 18 hours with free access to water [3]. Under ether anesthesia, a laparotomy was performed and the pylorus was ligated, the drug solution was administered through the probe - experimental groups: Nimesulide - experiment 1 (O1) and Lornoxicam - experiment 2 (O2), pH of the solutions of the injected drugs = 4.0 - 4.5, volume - 1 , 0ml, dose - 15mg/kg, the solution was shaken before administration. Control (С) - ligation of the pylorus and the introduction of 1.0ml of physiological saline. Autopsy after 2 hours, the animals were opened under ether anesthesia, and the abdominal cavity was examined. The pH and volume of the gastric contents were measured. Then using a magnifying glass examined the mucous membrane. Damage Index (ID), the total score of the identified lesions was calculated and divided by the number of animals. Points: edema=1; hyperemia=2; single hemorrhages=3; hemorrhages fused = 4; erosion = 5; ulcer = 6.

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