Significant of Antimullerian Hormone (AMH) as Fertility Marker_ Crimson Publishers

 Significant of Antimullerian Hormone (AMH) as Fertility Marker by Mohd Nizar Battikhi* in Developments in Clinical & Medical Pathology_ Journal of Medical Pathology

 

Introduction

AMH is defined as: “Anti-mullerian hormone, it is a protein released by the ovaries that start the growth of an egg in the ovaries and is related to the development of follicles in the ovary. AMH levels correspond to the number of antral follicles, that can be used to indicate the number of eggs available in the ovaries [1,2]. It is virtually undetectable but increases gradually until puberty and remains relatively stable through the reproductive period [3,4]. A very low level of AMH may indicate poor ovarian reserves. A very high level of AMH may correspond to PCOS. One of the best uses currently of the AMH test is the ability to titrate fertility medications based on ovarian reserve and the ability to differentiate between polycystic Ovary Syndrome (PCOS) and those potential donors with a PCOS like ovarian response. By utilizing AMH, those woman with higher numbers may stimulate faster on less fertility medication and it can help decrease hyper stimulation in the high AMH and basal antral follicle count donors [1].

Level of AMH hormone corresponds to the number of eggs a woman has left in her ovarian reserve. That decline with age, however, not every woman is borne with the same number of eggs or loses them at the same rate [5]. There are some factors influence ovarian reserve such as genetics, exposure to chemotherapy, radiation and some medical conditions [5]. AMH detection is very good test because it indicates some information about biological clock, where no reliable test give such information before. [5]. AMH can be tested on any day of the menstrual cycle and It’s levels correlate with the number of oocytes retrieved and treatment can be individualized for optimal cycle [6-8], although level variation between different blood samples for the same patient was reported during the same menstrual cycle especially in young patients [9,10] never the less AMH can still show 80% sensitivity and 93% specificity in predicting poor ovarian response at random blood test [11] and It’s levels correlate with the number of oocytes retrieved and treatment can be individualized for optimal cycle.

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