Virtual
Crossmatch in the Context of Kidney Transplantation by Beatriz Chamun Gil in
Experimental Techniques in Urology
& Nephrology: Journal
of Nephrology
The patient survival is strongly
influenced by the presence of DSA [1-5]. Currently, Virtual Cross Match (VXM)
has been used to predict the real crossmatch results by Complement-DependentCytotoxicity
(CDC) and Flow Cytometry crossmatch (FCXM) [6-10]. VXM compare donor HLA
antigens with anti-HLA antibodies in recipient serum. The antibodies are
detected by the Single Antigen (SA) assay, in which each bead is coated with a single
HLA specificity, detecting the precise anti-HLA antibodies and their levels,
allowing predict reactions against donor HLA
antigens. However, SA assays has some limitations that can, difficult the VXM
interpretation [11]. The SA assay show higher sensitivity whereas the CDC
and FCXM are specific against donor HLA molecules,
which suggests that methods may be complementary [7-10].
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