Advances in The Therapy of Depression by Ghassan Haddad in Techniques in Neurosurgery & Neurology: Crimson Publishers_Journal of Neurology Neurosurgery and Psychiatry

Depression is one of the most common serious medical and psychiatric disorders, with greater than 200 million adults worldwide suffering from major depressive disorder (MDD) at any given time, according to a 2003 report by the World Health Organization titled Investing in Mental Health. According to the U.S. National Comorbidity Survey Replication published in 2007, more than 16 million adults in the United States, which represents approximately 6.7% of itsentire adult population, will suffer from MDD in a 12-month period. The quest to come up with a superior antidepressant is in full effect among biotech and pharmaceutical companies. Although there are some companies that are still tweaking various formulations of serotonergic, noradrenergic, and dopaminergic substances i.e. triple reuptake inhibitors others are thinking outside the box.

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