Perspectives of Complement System in Inflammatory
Diseases by Lalit M Srivastava* in Advances in Complementary & Alternative
medicine-Crimson Publishers: Journal of Traditional and Complementary Medicine
The Complement System provides a rapid and
efficient means to protect the host from invasive microorganisms. Due to its
diverse biological activities, complement is the major mediator of
inflammation, a natural response to the host tissue to any injury. Evidences
are available to show that complement significantly contributes to the
regulation of immune response. Furthermore, the effector functions arising from
complement activation carry the potential for harming the host by directly or
indirectly mediating inflammatory tissue destruction. Inappropriate or
excessive activation of the complement system can lead to harmful, potentially
life-threatening consequences due to severe inflammatory destruction. Genetic
complement deficiencies or complement depletion have been found to be
beneficial in reducing tissue injury of severe complement dependent
inflammation.
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