Can we Optimize Immune Checkpoint Inhibitors Efficacy in Digestive Oncology?: Crimson Publishers

Can we Optimize Immune Checkpoint Inhibitors Efficacy in Digestive Oncology? by Anthony Lopez* in Crimson Publishers: Crimson research

Immunotherapy is revolutionizing oncology, with a simple guiding principle: the host immune system has the potential to eradicate cancer, treatment consisting in optimizing immune actors' functions. Although significant results were demonstrated in patients with melanoma or lung cancer, objective response rate (ORR) is only 20% in digestive oncology. However, we can improve this situation by a better knowledge of anti-tumor immunity. For example, ORR is multiplied by two to three in case of PD-L1 (programmed death-ligand 1) overexpression or microsatellite instability (MSI). In a near future, we will certainly be able to take into account other biomarkers for building composite scores for assigning to each patient with digestive cancer an 'immune identity card' able to strongly predict immunotherapy efficacy.

Gastroenterology Medicine & Research: Crimson Publishers

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https://www.crimsonpublishers.com/gmr/fulltext/GMR.000508.php

Curcuma zerumbet (Zingiberaceae) Rhizome Extracts Thermal Characterization Through TG, DTA and DSC Analysis_ Crimson Publishers

Curcuma zerumbet (Zingiberaceae) Rhizome Extracts Thermal Characterization Through TG, DTA and DSC Analysis by Castro M* in Journal of Biotechnology & Bioresearch

The present work aims to achieve the thermal characterization of the water and hydroalcoholic extracts from the rhizome of Curcuma zerumbet through TG, DTA and DSC thermoanalytic as well phytochemical analysis from three different geographical sites. Dynamical assays at the 30 to 300 °C range were conducted so as to ascertain whether the extracts could be utilized in every food production process regardless of their temperature and studied the essential oil from them through GC-MS. The expressed results indicated these extracts cannot be utilized in the food manufacturing processes above 100 °C due to the degradation of bioactive components such as curcuminoids and/or curzerenone, compounds with pharmacological properties.

https://crimsonpublishers.com/jbb/fulltext/JBB.000514.php

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Archaeology and Geophysics: Invincible Couple- Crimson Publishers

Archaeology and Geophysics: Invincible Couple by Mohamed A Rashed in Archaeology & Anthropology: Open Access: Crimson Publishers_ Journal of Archaeology

Today, there is almost no new archaeological discovery in which geophysical investigation tools do not play a key role. In fact, looking onto the past century, one could argue that geophysics, in a way, has rescued archaeology and revived it from its old-style techniques involving hard labor and time consuming digging and trenching. Today, thanks to geophysics, archaeology utilizes state-of the-art technologies, takes advantage of the most recent data management and processing techniques, and benefits from the latest image processing protocols. However, archaeology is not the only beneficiary from this successful coupling between archaeology and geophysics. Many of the advances in shallow and high-resolution geophysical techniques as well as data processing and interpretation capabilities can be indirectly attributed to the needs, demands and feedbacks of archaeologists. This successful exchange of benefits has resulted in a new scientific term that is commonly used nowadays; that is Archaeo geophysics or ArchaeologicalGeophysics.

https://crimsonpublishers.com/aaoa/fulltext/AAOA.000514.php

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Diathermy versus Scalpel in Abdominal Skin Incisions: Systematic Review_Crimson Publishers

Diathermy versus Scalpel in Abdominal Skin Incisions: Systematic Review by Abdelaal N in Perceptions in Reproductive Medicine: Crimson Publishers_Journal of Reproductive Health

Objectives: To compare the use of diathermy versus scalpel in abdominal skin incisions to see the variations in post operative pain, incision time, incision blood loss and wound complication rate.

Background: Surgical scalpels are traditionally used for making skin incisions during abdominal surgical operations. The great evolutions in the electrosurgical devices nowadays bring an alternative method for making skin incision by the usage of diathermy skin incision.

Data Sources: Medline databases (Cochrane reviews, PubMed, Medscape, Science Direct) and all materials available in the Internet from 2011 to 2017.

Study Selection: The initial search presented 157 articles of which 8 met the inclusion criteria. The articles were randomized controlled trials compared the use of surgical scalpel versus cutting diathermy in making skin incisions during abdominal operations.

Data Extraction: If the studies did not fulfill the inclusion criteria, they were excluded. Study quality assessment included whether ethical approval was gained, eligibility criteria specified, appropriate controls, adequate information and defined assessment measures.

Data Synthesis: Comparisons were made by structured review with the results tabulated.

Findings: The studies indicated that cutting diathermy could be accepted as an alternative method for abdominal skin incisions.

Conclusion: The studies stated that, the use of diathermy in skin incision during abdominal surgical operations was associated with less blood loss and shorter incision time than the scalpel skin incision. No increase in the postoperative pain and wound complications rate reported with the use of cutting diathermy for abdominal skin incisions.

https://crimsonpublishers.com/prm/fulltext/PRM.000517.php

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Effect of Rainfall Trend on Yam Yield in Mokwa Local Government Area of Niger State, Nigeria: Environmental Sciences

Effect of Rainfall Trend on Yam Yield in Mokwa Local Government Area of Niger State, Nigeria by Mohammed J Mamman* in Environmental Sciences

Agricultural production in Niger State like other states in Nigeria is highly vulnerable to climate changeability. Climate change is predicted to have adverse effects on the agricultural sector of the poorer parts of the world especially sub-Saharan Africa. The aim of the study is to investigate and analyse the effect of rainfall trend on the production of yam in Mokwa local government area of Niger state, Nigeria. For the purpose of this research, data were collected from 100 respondents through the administration of questionnaires. Rainfall data covering a period of thirteen years (2003-2015) were also obtained from College of Agriculture Mokwa weather station, while the yearly yam yield for 16 years (2000-2015) was obtained from Niger State Ministry of Agriculture.

Linear regression models and standardized anomaly index were used to analysis the data gathered. The study showed that the trend of mean annual rainfall in the study area was minimal but significant with R2 value of 0.8 for mean monthly rainfall. A strong relationship between rainfall variation and yam yield exist with r2 value of 0.881. The variation in the yield among the years was moderately significant with R2 value of 0.5064. It also showed a positive response between yam yield and moderate rainfall that was well distributed. Extension agent from ministries of agriculture and ADPs should do more in harnessing relevant information on food production in all the local government areas of Niger state so as to build a robust data bank for further research.

https://www.crimsonpublishers.com/eaes/fulltext/EAES.000512.php

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Challenge in Structural Behaviours of Corroded Pre-stressed Concrete Beams_ Crimson Publishers

Challenge in Structural Behaviours of Corroded Pre-stressed Concrete Beams by Lei Wang* in Evolutions in Mechanical Engineering

Strand corrosion is one of the main causes for the deterioration of Pre-stressed concrete structures. Corrosion decreases strand cross-section, causes material deterioration, induces concrete cracking, degrades bond strength and deteriorates the capacity of PC beams. As the high-stress level of prestressing strand, strand corrosion causes a brittle failure of PC beams without warnings. The potential dangers of corrosion in PC beams would be much more severe than that in reinforced concrete members. The structural behaviors should be thoroughly investigated to insure the serviceability and safety of corroded PC beams.

https://www.crimsonpublishers.com/eme/fulltext/EME.000507.php

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Feasibility study on small scale food production using off-grid photovoltaic water pumping system in coastal dune_Crims

Feasibility study on small scale food production using off-grid photovoltaic water pumping system in coastal dune by Xinyan Wang, Kotaro Tagawa* and Bateer Baiyin in Crimson Publishers: Open Journal of Civil Engineering

A small-scale food production which is combined an off-grid photovoltaic water pumping system with vegetable cultivation was tested. The groundwater at seashore in coastal dune are irrigated to cultivate Swiss chard. The practicability of off-grid photovoltaic water pumping system and availability of groundwater in coastal dune are suggested.

https://crimsonpublishers.com/acet/fulltext/ACET.000523.php

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Obstructed Diaphragmatic Hernia in Children: Report of Two Cases: Crimson Publishers

Obstructed Diaphragmatic Hernia in Children: Report of Two Cases by Samiul Hasan in Research in Pediatrics & Neonatology:  Children 

Congenital diaphragmatic hernia usually present in early neonatal period. Few cases present later in child hood with respiratory symptoms but presenting with intestinal obstruction is very rare. We describe two patients of congenital diaphragmatic hernia presenting with intestinal obstruction.

https://crimsonpublishers.com/rpn/fulltext/RPN.000519.php

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Holy Good Friday | Crimson Publishers

Wish you and your family a blessed Good Friday!!

Relativistic Complex_Crimson Publishers

Relativistic Complex by Boris Dzhechko in COJ Technical & Scientific Research: Crimson Publisher_Technical and Scientific Research

In the thought experiments of the theory of relativity there is always a movement of the signal at the speed of light. In this case, the light signal in this theory exists only in the imagination. However, in new Cartesian physics, it exists in reality as a shift of space propagating with the speed of light, because according to the principle of identity of physical space and matter of Descartes, the real world is created by a single moving substance, which should be called space-matter, there is nothing else in it. The beginning shift of space ends on itself with filling with the speed of light of emptiness formed behind it as a result of its shift. In addition, space serves as a conductor of electromagnetic waves, representing its wave-like shifts.

https://crimsonpublishers.com/cojts/fulltext/COJTS.000517.php

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Free Amino Acid and Their Derivatives: Plastic Substrates, Specific Regulators of Metabolism and Markers | Crimson Publishers

Free Amino Acid and Their Derivatives: Plastic Substrates,Specific Regulators of Metabolism and Markers by Nefyodov L in Journal of Medical Sciences & Health

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On the basis of the experimental data we suggest that the differences discovered in certain amino acids concentrations in blood plasma, red blood cells and tumors are criteria in early diagnostics of primary cancerous growth as well as in estimation of the efficacy of specific cancer treatment. Clinical studies on biological fluids and tumors of 1,495 patients with cancer of the mammary gland, lungs, prostate, ovaries, bladder or digestive tract showed significant changes in physiological concentrations of amino acids which either directly or indirectly regulate processes of antitumor response, oncogenesis, immunogenesis and apoptosis were shown. Our strategy of application of amino acids as medicinal preparations includes a targeted effect on the functional and metabolic relationships which are changed in specific pathology through the effect on the regulatory mechanisms of intermediate metabolic reactions, limiting stages of metabolic flows, utilization of energy substrates and transport systems restricting the processes of amino acids pool formation. The creation methodology of pathogenetic compositions of amino acids and their derivatives on the basis of their physiological concentration for practical application of their regulatory effects in oncology was discussed.

https://crimsonpublishers.com/rmes/fulltext/RMES.000522.php

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Evaluation of Air Flow Characteristics of Aerostatic Thrust Porous Bearings: A Numerical Approach: Crimson Publishers

Evaluation of Air Flow Characteristics of Aerostatic Thrust Porous Bearings: A Numerical Approach by Marcelo Gustavo Coelho Resende, Leandro José da Silva, Cláudio de Castro Pellegrini and Túlio Hallak Panzera* in Crimson Publishers: Structural engineering

Aerostatic porous bearings have been investigated in the last decades for precision engineering designs, since these bearings offer zero-friction and high operating speeds, as well as providing a very precise positioning system without external influence. Numerical methods such as CFD (Computational Fluid Dynamics) play an important role in the design and behavior analysis of porous aerostatic bearings, being possible to adjust the geometry and characteristics of the porous restrictor even before its manufacture In the present work, the behavior of the gas at the inlet and outlet of a porous thrust bearing made of cementitious composites is analysed by numerical simulation using CFD method. The results reveal a stable behavior of the cementitious porous bearing and a good correlation between numerical and experimental load capacities.

https://crimsonpublishers.com/eme/fulltext/EME.000520.php

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