Augmenter of Liver Regeneration in ROS-induced Pathophysiological Conditions by Sudhir Kumar in-Open Access Research in Anatomy: Crimson Publishers_Annals of Anatomy
Augmenter of liver regeneration (ALR), also described as hepatopoietin (HPO) and hepatic stimulator substance or hepatic regenerative stimulation substance (HSS), is representative member of ERV protein family with flavin-linked sulfhydryl oxidase activity, that facilitate the formation of disulfide bonds in reduced protein substrates [1]. Growing numbers of evidence demonstrate the involvement of ALR in maintaining cellular redox communication under various pathophysiological conditions [2-7]. Understanding redox regulation and precise assessment of metabolic/oxidative stress are key to monitor diverse range of pathophysiological events, since a large number of cellular functions and dysfunctions are, either directly or indirectly, triggered in response to redox signals
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