Predictors of Ovarian Reserve and Ovarian Stimulation Outcome in Infertile Women by Juliano Brum Scheffer* in Perceptions in Reproductive Medicine
The fecundity of women begins to decrease after the age of 30 years, primarily as a result of a decrease in the proportion of normal eggs available, which in turn is a consequence ofa continuous process of oocyte atresia. Although all women experience this decrease in fecundity, it is difficult to predict the pace of reproductive decline in an individual woman. This age-related decline in fecundity is characterized by a decrease in both egg quality and number, and a population-based change in the expression of markers of ovarian activity, such as a gradual increase in circulating FSH and decreases in circulating anti-Mullerian hormone (AMH) and inhibin B concentrations.
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