Liver Fibrosis: Difficulties in Diagnostic and Treatment: A Review by Florian Bert*
in
Early discovery of liver fibrosis
and cirrhosis is becoming more relevant because of enhanced incidence of
hepatocellular carcinoma. There a many underlying factors in developing liver
fibrosis (i.e. viral hepatitis, steatohepatitis). Diagnosis of liver fibrosis
is difficult; chronic liver failure and less distinct fibrosis stages can be
underestimated, when laboratory routine parameters and native ultrasound of the
liver are unsuspicious. Liver biopsy is a common element of diagnostic workup
in hepatic cirrhosis, alongside clinical examination and abdominal ultrasound,
and is the accepted diagnostic gold standard. But there is no unitary system of
histological classification used to evaluate the degree of fibrosis, and
individual systems are often validated only for individual disease entities. On
the other hand liver biopsy is of less tolerance for patients. In the last
years serological markers for detecting liver fibrosis were developed with
different validity. Various imaging modalities have been proposed as methods
for assessing liver fibrosis by liver stiffness measurement.
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