Evaluation of A Lactic Acid Based Probiotic on Leaky Gut and Microbiome Associated with Salmonella Enteritidis Infection and Feed Restriction in Broiler Chickens by Guillermo Tellez in
The
objective of the present study was to evaluate the effect of a lactic acid
based probiotic on leaky gut and microbiome associated challenges with Salmonella
Enteritidis infection and 24h feed restriction (FR) in broiler chickens.
Chickens were orally gavaged with 2x104cfu/chick of S.
Enteritidis at 1 d of age and then were randomly assigned to one of four
groups: 1) Control, 2) Probiotic control, 3) FR, and 4) Probiotic+FR. The
probiotic was included in the drinking water for 16 days. Blood samples were
collected for measuring leakage of FITC-d, and ceca content was also collected
for microbiome evaluation. In the present study, the probiotic reduced FITC-d
when compared with FR chickens without the probiotic. At Phylum level, both
groups treated with probiotic had higher proportion of Firmicutes and
Bacteroidetes. At the Class level, both control groups in this trial had an
increase in Gammaproteobacteria. This study confirms that FR increases gut
permeability in chickens, but these changes were prevented by the
administration of a lactic acid based probiotic.
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