Broadening the Spectrum of Diffusion Weighted
Imaging to Evaluate Marrow Pathologies by Meena GL in Crimson Publishers: Bone
disease
Objectives:
To evaluate the signal characteristics of normal adult bone marrow in whole-body
diffusion-weighted (DW) images (WB-DWI), to correlate these characteristics
with age and gender, and to determine the causes of these phenomena.
Material and
Methods: Ninety-eight healthy volunteers underwent WB-DWI (b=0 and
800s/mm2). Two radiologists visually evaluated the signal characteristics of
bone marrow in DW images separately. One radiologist measured the apparent
diffusion coefficient (ADC) of the thoracic and lumbar vertebrae, bilateral
femur (including head, neck, and proximal and distal femoral shaft), bilateral
humeral head, ilium, and scapula. The signal characteristics of normal bone
marrow were analyzed.
Results:
The visual evaluation results of DW images indicated that hyperintensity of
bone marrow was more frequently seen in women aged 21-50 years (68.4%) than in
men aged 21-50 years (3.3%) (P <0.001), men aged 51-81 years (5.9%)
(P<0.001), and women aged 51-81 years (15.4%) (P=0.001). However, no
statistically significant difference was found between men and women aged 51-81
years (P=0.565). The ADC of bone
marrow was significantly higher in women than in men aged 21-50
years. Bone marrow ADC showed significant negative correlation with age in
women but
not
in men.
Conclusion:
The signal intensity of bone marrow varies with age and gender in DW images.
ADC and the T2 shine through effect contributed to the bone marrow signal
intensity in DW images, and the latter effect may predominate.
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